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1994-08-09
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Document 0190
DOCN M9480190
TI Fetal immunological and haematological changes in intrauterine
infection.
DT 9410
AU Thilaganathan B; Carroll SG; Plachouras N; Makrydimas G; Nicolaides KH;
Harris Birthright Research Centre for Fetal Medicine, King's; College
Hospital School of Medicine, London, UK.
SO Br J Obstet Gynaecol. 1994 May;101(5):418-21. Unique Identifier :
AIDSLINE MED/94289360
AB OBJECTIVE: To study fetal immunological and haematological changes to
intrauterine infection. DESIGN: In 37 pregnancies at risk of
intrauterine infection, fetal blood obtained by cordocentesis at 20 to
36 weeks gestation was used for differential leucocyte counts, platelet
count, enumeration of lymphocyte subpopulations, and neutrophil adhesion
receptor expression. SETTING: Harris Birthright Research Centre for
Fetal Medicine, London. RESULTS: All four fetuses with viral infections
had platelet counts below the 5th centile and three had natural killer
(NK) cell counts greater than the 95th centile of the normal range.
Similarly, all five fetuses with bacterial or candidal infection had
neutrophil counts greater than the 95th centile of the normal range;
lymphocyte subpopulations were normal. CONCLUSIONS: In pregnancies
complicated by intrauterine infection, fetuses exhibit NK cell
lymphocytosis and thrombocytopenia in response to viraemia, and
neutrophilia in response to bacteraemia from at least 21 weeks
gestation.
DE Bacterial Infections/BLOOD/*IMMUNOLOGY CD4-CD8 Ratio Female Fetal
Blood Fetal Diseases/BLOOD/*IMMUNOLOGY Human Killer Cells,
Natural/*IMMUNOLOGY Leukocyte Count Neutropenia/ETIOLOGY Platelet
Count Pregnancy Pregnancy Complications, Infectious/*IMMUNOLOGY
Support, Non-U.S. Gov't Thrombocytopenia/ETIOLOGY Virus
Diseases/BLOOD/*IMMUNOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).